NOVEL PROCESS FOR DEVITALIZED/ACELLULAR TISSUE FOR TRANSPLANTATION
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United States of America Patent
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Issued Date -
Feb 4, 2010
app pub date -
Oct 18, 2007
filing date -
Oct 18, 2006
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Abstract
A method for processing tissue to produce a devitalized acellular matrix for transplantation comprises soaking the tissue in a first processing solution having a pH below 7 to reduce protease activity, periodically infusing ozone into the first processing solution to devitalize the tissue and reduce bioburden, and soaking the tissue in a second processing solution to remove cellular debris. The present invention also includes a system for processing the tissue. The devitalized acellular matrix acts as a scaffold for cellular ingrowth when transplanted into a recipient to form new tissue.
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