Shoes with customized side panels including hand gesture elements are disclosed herein. In one embodiment, a shoe can include a sole assembly and an upper coupled to the sole assembly and including a first side panel and a second side panel generally opposite the first side panel. The shoe also includes a hand gesture element on at least one of the first side panel and the second side panel. The hand gesture element can include any type of hand gesture that is expressive of an idea, opinion, emotion, etc. It is emphasized that this abstract is provided to comply with the rules requiring an abstract. It is submitted with the understanding that it will not be used to interpret or limit the scope or meaning of the claims (37 C.F.R. 1.72(b)).

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