FLAGELLIN MUTANT VACCINE
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United States of America Patent
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Issued Date -
Jan 21, 2010
app pub date -
Jul 17, 2007
filing date -
Jul 21, 2006
priority date (Note) -
Abandoned
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Abstract
The present invention provides a vaccine which effectively induces protective immune response particularly against flagellated pathogens (such as Pseudomonas aeruginosa). A flagellin mutant into which a mutation has been introduced at least at one site in the Toll-like receptor 5 activation domain of a corresponding wild-type flagellin to thereby attenuate the ability to activate Toll-like receptor 5. A vaccine targeting the flagellin mutant.
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