METHODS AND COMPOSITIONS FOR THE UTILIZATION AND TARGETING OF OSTEOMIMICRY

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United States of America Patent

SERIAL NO

12343063

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Abstract

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A method for interfering with osteomimetic properties of a cell includes introducing into the cell an osteomimecry-interfering compound, wherein said osteomimecry-interfering compound prevents or ameliorates the expression of the osteomimetic properties of said cell. A method for treating or ameliorating an osteotropic-related cancer or disorder in a subject includes administering to the subject an osteomimecry interfering compound. A method for identifying a compound that modulates the osteomimetic potential of a cell includes contacting a cell exhibiting osteomimetic potential with a test compound; measuring expression levels of one or more osteomimetic gene products in the cell in the presence and in the absence of the test compound; and identifying a compound that modulates the osteomimetic potential, wherein the compound changes the expression levels of one or more osteomimetic gene products in the cell.

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Patent Owner(s)

Patent OwnerAddress
DA ZEN GROUP LLCC/O CEDARS-SINAI MEDICAL CENTER 8750 BEVERLY BOULEVARD ATRIUM 103 LOS ALAMITOS CA 90048

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Chung, Leland W K Atlanta, US 18 50
Hsieh, Chia-Ling Decatur, US 6 15
Huang, Wen-Chin Atlanta, US 9 26
Odero-Marah, Valerie Tucker, US 4 3
Wu, Daqing Atlanta, US 66 838
Zhau, Haiyen Atlanta, US 3 3

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