METHOD FOR MEASURING THE CONCENTRATION OF ACTIVATED FACTOR VII (FVIIA) IN A SAMPLE
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United States of America Patent
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Issued Date -
Jan 14, 2010
app pub date -
Dec 28, 2007
filing date -
Dec 29, 2006
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Abandoned
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Abstract
The present application concerns a method for the in vitro or ex-vivo measurement of the FVIIa concentration of a sample, comprising the steps consisting of: a) mixing said sample with a human plasma deficient in FVII and in at least one other factor chosen from among FVIII, FIX and FXI; b) adding initiator components of the thrombin generation reaction, comprising a source of calcium ions, a phospholipid agent and tissue factor; c) performing a thrombin generation test (TGT) on the reaction medium so obtained, to obtain a thrombogram giving parameters; d) comparing at least one of the parameters of the thrombogram with a homologous parameter of standard thrombograms, each standard thrombogram being obtained with a fixed, calibrated concentration of FVIIa in said reaction medium, lying a range of 1 pM to 5 nM, and e) deducing from step d) the measurement of the FVIIa concentration of the sample, lying within said range.
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