DRUG DELIVERY COATING FOR USE WITH A MEDICAL DEVICE AND METHODS OF TREATING VASCULAR INJURY
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United States of America Patent
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Issued Date -
Jan 7, 2010
app pub date -
Apr 28, 2006
filing date -
Apr 29, 2005
priority date (Note) -
Abandoned
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Abstract
The present inventions provide various embodiments of methods for one or more of treating vascular injury, neointima proliferation and/or local inflammation in a mammal by locally administering therapeutic compound comprising a mTOR targeting compound and a calcineurin inhibitor. In various aspects, the therapeutic compound comprises a bio-absorbable carrier component carrier component at least partially formed of a cellular uptake inhibitor and a cellular uptake enhancer, a mTOR targeting compound and a calcineurin inhibitor. In various aspects, the present invention provides for controlled delivery, which is at least partially characterized by total and relative amounts of a cellular uptake inhibitor and cellular uptake enhancer in a bio-absorbable carrier component.
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