METHOD FOR REDUCING FUCOSE CONTENTS OF RECOMBINANT PROTEINS
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United States of America Patent
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Issued Date -
Jan 7, 2010
app pub date -
Jan 9, 2009
filing date -
Jul 3, 2008
priority date (Note) -
Abandoned
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Abstract
The present invention relates to a method for reducing the fucose content of a recombinant protein, which comprises expressing in an animal cell the recombinant protein and FUCA1, an FUCA1 mutant, FUCA2, or a fragment of FUT8 localization domain; or with a fusion protein of a fragment of FUT8 localization domain and a fragment of FUCA1, a FUCA1 mutant or FUCA2. Therefore, the antibody expressed according to the method of the present invention exhibits a reduced fucose content in their Fc regions, which leads to the improvement in the therapeutic effect thereof.
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