Process for the Preparation of Biphosphonic Acids and Salts Thereof
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United States of America Patent
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app pub date -
Nov 6, 2007
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Nov 6, 2006
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Abstract
A process for the preparation of biphosphonic acids and pharmaceutical acceptable salts thereof, comprises reacting a carboxylic acid with phosphorous trichloride and phosphorous acid in the presence of an aprotic polar solvent. Formula (I):
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