CHIMERIC VACCINE ANTIGENS AGAINST THE AVIAN INFLUENZA VIRUS
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United States of America Patent
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Issued Date -
Dec 31, 2009
app pub date -
Feb 28, 2007
filing date -
Feb 28, 2006
priority date (Note) -
Abandoned
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Abstract
The present invention describes chimeric vaccine antigens against the avian influenza virus (AIV). Said vaccine antigens are based on viral subunits that are coupled to protein molecules that stimulate not only the cellular but also the humoral immune system. The chimeric antigens may be produced in expression systems that guarantee correct three-dimensional folding of the chimeric molecules that constitute the basis of the present invention. The vaccine compositions that contain said chimeric antigens induce a potent, early immune response both in birds and in vaccinated mammals, stimulating high haemagglutinin-inhibiting antibody titres and a potent specific cellular response against the viral antigen. The chimeric antigens, and also the resulting vaccine compositions, are applicable to the field of human and animal health as vaccines for preventive use.
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