METHOD FOR REMOVAL OF NUCLEIC ACID-PROTECTING GROUP
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United States of America Patent
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Issued Date -
Dec 17, 2009
app pub date -
Feb 26, 2007
filing date -
Feb 27, 2006
priority date (Note) -
Abandoned
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Abstract
A method is provided for efficiently removing the silicon substituent which protects the 3′-hydroxyl group and the 5′-hydroxyl group of a ribose of a ribonucleic acid derivative in which the 2′-hydroxyl group of the ribose is protected with the following substituent (I)where WG1 represents an electron withdrawing group, and the 3′-hydroxyl group and the 5′-hydroxyl group of the ribose are protected with a silyl protecting group.
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