BIOMATERIALS FOR REGENERATIVE MEDICINE
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United States of America Patent
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Issued Date -
Dec 17, 2009
app pub date -
Sep 13, 2006
filing date -
Sep 16, 2005
priority date (Note) -
Abandoned
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Abstract
It was examined whether a cartilage-like tissue is formed under various reaction conditions using cartilage matrix components: glycosaminoglycan, proteoglycan, and collagen. The present inventors have discovered that proteoglycan bound to glycosaminoglycan through self-organization form an aggregate when the glycosaminoglycan was reacted with proteoglycan under specific concentrations and pH, and that a mesh structure composed of collagen fibers was constructed through self-organization using the aggregates as a skeleton when the aggregates were reacted with collagen molecules.
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