Multiple modified derivatives of gelatin and crosslinked material thereof

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United States of America Patent

PATENT NO 8158754
APP PUB NO 20090306345A1
SERIAL NO

12522476

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Abstract

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Disclosed is a kind of multiple modified derivatives of gelatin having not only the structure of formula (I) but also one of structures of formula (II), (III), and (IV) as well, wherein, G refers to gelatin residue, which can be type A, type B or a gelatin obtained from gene recombination; R1 refers to alkylene, or a linkage group with amide; R2 refers to alkyl, or aryl; R3 refers to alkylene; and R4 refers to carboxyl or carboxylate. The multiple modifying ways of gelatin comprise the hydrophobic modification on the amino group of gelatin through amide bond, carboxylation on the amino group of gelatin through amide bond, thiolation on the carboxyl group of gelatin, and thiolation following carboxylation on amino group of gelatin through amide bond. Also disclosed is a crosslinked material made of multiple modified derivatives of gelatin. The multiple modified derivatives of gelatin have flexible chemical structures and many properties. Their crosslinked gelatin material can be used the matrix for cell growth, etc.

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Patent Owner(s)

Patent OwnerAddress
BIOREGEN BIOMEDICAL (CHANGZHOU) CO LTDBUILDING B NO 117 XUEYE ROAD XINBEI DISTRICT CHANGZHOU JIANGSU 213125 CHINA

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Song, Chan Shanghai, CN 4 6

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