G-CSF DERIVATIVE FOR INDUCING IMMUNOLOGICAL TOLERANCE

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United States of America Patent

SERIAL NO

12544870

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Abstract

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The invention relates to a method for inducing immunological tolerance, in particular transplantation tolerance, by administering a G-CSF derivative or biologically active fragment, homolog, or variant thereof, in particular peg-G-CSF, to a donor cell or a transplantation donor. The invention also relates to expanding and stimulating selected donor cells by administering a G-CSF derivative, preferably peg-G-CSF. The donor cells are preferably granulocyte-monocyte precursor cells and IL-10 secreting T cells.

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Patent Owner(s)

Patent OwnerAddress
THE COUNCIL OF THE QUEENSLAND INSTITUTE OF MEDICAL RESEARCHHERSTON QUEENSLAND 4006

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
HILL, Geoffrey Hawthorne , AU 9 2
MACDONALD, Kellie Wishart , AU 2 0
MORRIS, Edward Long Sutton , GB 21 454

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