Compositions and methods for stabilizing liposomal drug formulations
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United States of America Patent
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Issued Date -
Nov 19, 2009
app pub date -
Nov 4, 2005
filing date -
Nov 5, 2004
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Abstract
The present invention is directed to liposomal compositions comprising a camptothecin, which are optimized to reduce camptothecin degradation and/or precipitation of camptothecin degradation products in the external medium. The invention further provides improved methods of formulating liposomal camptothecins, kits comprising liposome-encapsulated camptothecins, and methods of using the same to treat a variety of diseases and disorders, including cancer.
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