APPARATUS AND METHOD FOR EXTERNAL FLUORESCENCE IMAGING OF INTERNAL REGIONS OF INTEREST IN A SMALL ANIMAL USING AN ENDOSCOPE FOR INTERNAL ILLUMINATION
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United States of America Patent
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app pub date -
Jun 16, 2009
filing date -
Sep 8, 2005
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Abandoned
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Abstract
An apparatus for capturing an optical molecular image of one or more internal regions of interest of a small animal having a cranio-caudal axis. The apparatus may include a support member for the animal in an immobilized state; an endoscope for insertion into and withdrawal from the body of the animal to allow the endoscope to be positioned selectively proximate the internal regions of interest within the body; a light source connected to the endoscope to provide illumination within the body at the regions of interest; a mechanism for rotating the animal about its cranio-caudal axis to enable image capture from different angles; and a device for capturing images of the one or more internal regions of interest from the different angles, due to light emitted from the one or more internal regions of interest through an external surface of the body in response to illumination from the light source. A corresponding method is disclosed.
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