Tight Junction Modulating Peptides for Enhanced Mucosal Delivery of Therapeutic Compounds
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United States of America Patent
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Issued Date -
Nov 5, 2009
app pub date -
Jun 8, 2009
filing date -
Dec 16, 2005
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Abstract
Compositions and methods are provided that include a biologically active agent and a permeabilizing agent effective to enhance mucosal delivery of the biologically active agent in a mammalian subject, in which the permeabilizing peptide is a tight junction modulating peptide (TJMP), a TJMP analogue, a conjugate of a TJMP, a conjugate of a TJMP analogue, or complexes thereof. The permeabilizing agent reversibly enhances mucosal epithelial paracellular transport, typically by modulating epithelial junctional structure and/or physiology at a mucosal epithelial surface in the subject.
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