METHOD AND SYSTEM FOR SELECTING CHEMOTHERAPEUTIC AGENTS
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United States of America Patent
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Issued Date -
Oct 29, 2009
app pub date -
Apr 24, 2009
filing date -
Apr 24, 2008
priority date (Note) -
Abandoned
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Abstract
Described herein is a method and corresponding system, including reagents and assays, for determining the in vivo efficacy of drugs in the course of chemotherapy. The method can include identifying a patient having a condition, such as leukemia, that is potentially susceptible to one or more candidate drugs having a particular in vivo biochemical activity, such as the generation of reactive oxygen or nitrogen species. An in vitro biochemical assay is provided that corresponds to the biochemical activity, and a tissue sample is tested to determine the responsiveness of the tissue sample to the biochemical activity, for instance, the ability of the tissue sample to degrade or inhibit the active species (in this case, hydrogen peroxide), and thereby prevent its desired effect against the cancerous cells. A course of chemotherapy can be based, at least in part, on the responsiveness of the tissue sample to the biochemical activity.
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