Composition of Rapid Disintegrating Direct Compression Buccal Tablet
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United States of America Patent
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Issued Date -
Oct 22, 2009
app pub date -
Apr 14, 2009
filing date -
Apr 16, 2008
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Abstract
A composition of a rapidly disintegrating buccal dosage form containing a drug, at least one non-effervescent base such as an alkali metal or alkaline earth metal oxide or hydroxide, and a disintegrant. The base regulates the pH gradient to deliver the drug to the buccal, sublingual or oral mucosal membranes at a desired rate of absorption. The composition is micronized for uniform distribution, and the drug is converted from ionized form to unionized form, without the use of an effervescent agent.
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