ANTIFOLATE COMPOSITIONS
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United States of America Patent
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Issued Date -
Oct 8, 2009
app pub date -
Apr 7, 2009
filing date -
Apr 7, 2008
priority date (Note) -
Abandoned
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Abstract
The present invention provides pharmaceutical compositions comprising an antifolate compound. The composition exhibit improved bioavailability, and they particularly incorporate beneficial excipients that increase solubility and bioavailability, such as cyclodextrins or compounds formed of fatty acid esters of glycerol and polyethylene glycol esters. The pharmaceutical compositions are useful in the treatment of multiple conditions, including abnormal cell proliferation, inflammatory diseases, asthma, and arthritis.
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