GATIFLOXACIN-CONTAINING AQUEOUS LIQUID PREPARATION, ITS PRODUCTION AND METHOD FOR SUPPRESSING FORMATION OF PRECIPITATE DURING STORAGE AT LOWER TEMPERATURE AND AT THE TIME OF FREEZING AND THAWING OF THE AQUEOUS LIQUID PREPARATION
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United States of America Patent
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Issued Date -
Oct 1, 2009
app pub date -
Mar 31, 2009
filing date -
Mar 31, 2008
priority date (Note) -
Abandoned
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Abstract
There is provided an aqueous liquid preparation comprising 0.65 to 2 w/v % of Gatifloxacin or a pharmacologically acceptable salt thereof or a hydrate thereof as free Gatifloxacin, and at least 0.5 w/v % of at least one of the ingredient selected from the group consisting of phosphoric acid, malonic acid, nicotinamide and a salt thereof, wherein a pH thereof is 5.8 to 6.9. In the aqueous liquid preparation, the solubility of Gatifloxacin is increased and the formation of a precipitate during storage at a lower temperature and at the time of freezing and thawing of the aqueous liquid preparation is suppressed by incorporating at least one of the ingredient selected from the group consisting of nicotinamide, caffeine, methylglucamine and Methyl parahydroxybenzoate into the aqueous liquid preparation.
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