METHOD FOR ENCODING AND SCREENING COMBINATORIAL LIBRARIES

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United States of America Patent

APP PUB NO 20090247420A1
SERIAL NO

12096928

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Abstract

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A method of screening a library comprising: (i) providing either (a) a library comprising more than one copy of different library members, each copy of a different library member attached to a different releasable tag through a releasable covalent bond; where a plurality of tags uniquely encode each library member; or (b) a library comprising one or more copies of a library member attached to a support, with a plurality of tags uniquely encoding each library member; or (c) a library comprising different library members, each different library member attached to a plurality of tags uniquely encoding the different library member; (ii) providing a target compound with tethered sensitizer in specific binding proximity to the library, allowing specific binding of the target compound with tethered sensitizer to a selected library member; (iii) exciting the tethered sensitizer with excitation photoradiation, whereby the releasable tags attached to the selected library member are released; and (iv) detecting the releasable tags.

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Patent Owner(s)

Patent OwnerAddress
COLORADO SEMINARY WHICH OWNS AND OPERATES THE UNIVERSITY OF DENVER2199 SOUTH UNIVERSITY BOULEVARD DENVER CO 80208-4820

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Kottani, Rudresha Tucson , US 4 4
Kutateladze, Andrei G Centennial , US 4 4
Majjigapu, Janaki Menomonee , US 4 4
Valiulin, Roman Denver , US 1 1

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