CHROMOGENIC IN SITU HYBRIDIZATION METHODS, KITS, AND COMPOSITIONS
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United States of America Patent
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app pub date -
Aug 17, 2007
filing date -
Sep 14, 2000
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Abandoned
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Abstract
The present invention relates to chromogenic (calorimetric) in situ hybridization (CISH) and nucleic acid probes useful for in situ hybridization. Specifically, the present invention provides methods, kits, and compositions for performing bright field cancer diagnostics employing chromogenic in situ hybridization (e.g. to detect gene amplifications, gene translocations, and chromosome polysomy). In preferred embodiments, the present invention provides CISH methods, kits and compositions for detecting HER2 gene status.
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