Methods Of Dosing Propofol Prodrugs For Inducing Mild To Moderate Levels Of Sedation
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United States of America Patent
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Issued Date -
Sep 3, 2009
app pub date -
Jul 11, 2006
filing date -
Jul 12, 2005
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Abandoned
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Abstract
A dosage of a propofol prodrug needed for inducing mild to moderate sedation levels in a patient is calculated based on a patient's lean body mass. It has been discovered dosages based on gross body mass may result in overdosing, particularly for obese patients. In another aspect, a dosage suitable for inducing mild to moderate sedation levels in a patient who is at least 60 years of age is determined. A weight-appropriate dosage for the patient is determined and then adjusted by an age-based factor. For example, the dosage needed to produce a sedated state or other effect in a patient who is 60 years of age or older may be about 0.6-0.8 times the dosage needed to produce a corresponding effect in a younger patient of the same weight.
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