Site specific pegylated hemoglobin, method of preparing same, and uses thereof
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United States of America Patent
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Issued Date -
Aug 27, 2009
app pub date -
May 10, 2006
filing date -
May 11, 2005
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Abstract
The present invention provides pegylated hemoglobins comprising a maleimide polyethylene glycol (PEG) conjugated to a thiol moiety of a cysteine residue of hemoglobin, methods of preparing the pegylated hemoglobins, compositions and blood substitutes comprising the pegylated hemoglobins, and methods of treating a subject which comprise administering to the subject blood substitutes comprising vasoinactive pegylated hemoglobins.
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