Genetically modified microorganism and process for production of macrolide compound using the microorganism
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United States of America Patent
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Issued Date -
Aug 27, 2009
app pub date -
May 24, 2006
filing date -
May 26, 2005
priority date (Note) -
Abandoned
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Abstract
A genetically modified microorganism capable of directly producing a 16-hydroxylated macrolide compound; and a process for producing a 16-hydroxylated macrolide compound using the microorganism. Specifically, a genetically modified microorganisms having DNA encoding a polypeptide involved in the biosynthesis of a macrolide compound pladienolide and DNA encoding a polypeptide having a pladienolide 16-hydroxylase activity; and a process for producing a 16-hydroxylated macrolide compound comprising the steps of culturing the genetically modified microorganism in a culture medium and collecting a 16-hydroxylated macrolide compound from the culture medium.
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