METHOD OF ASSESSING CANCEROUS CONDITIONS AND REAGENT FOR DETECTING GENE PRODUCT TO BE USED IN THE METHOD
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United States of America Patent
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Issued Date -
Aug 27, 2009
app pub date -
Dec 15, 2005
filing date -
Dec 17, 2004
priority date (Note) -
Abandoned
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Abstract
It is intended to provide a method of assessing cancerous conditions, which is useful in diagnosing cancer in a therapy or a preventive therapy for cancer diseases or a maintenance therapy therefor, and a reagent for detecting a gene product to be used in the above method. The cancerous conditions of a human-origin specimen is assessed by using, as an indication, the content of a gene product, which shows an increase or a decrease in the expression thereof due to an unusual alternative splicing, from gene products obtained from human PTCH1 gene contained in the human-origin specimen. To measure the content, use is preferably made of, concerning at least one base sequence selected from the group consisting of (a) the base sequences represented by SEQ ID NOS:1 to 4 and (b) base sequences derived from any of the base sequences represented by SEQ ID NOS:1 to 4 by deletion, substitution and/or insertion of one to several bases and having an activity of being hybridized with a chain complementary to the corresponding base sequence selected from the base sequences represented by SEQ ID NOS:1 to 4 under stringent conditions, a probe sequence-specifically binding to the complementary chain of the above-described base sequence or a chemical modification thereof.
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