NANOPARTICLES WITH LIPID CORE AND POLYMER SHELL STRUCTURES FOR PROTEIN DRUG DELIVERY PREPARED BY NANOENCAPSULATION
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United States of America Patent
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Issued Date -
Aug 27, 2009
app pub date -
Dec 1, 2006
filing date -
Apr 5, 2006
priority date (Note) -
Abandoned
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Abstract
The present invention relates to an application of stabilized nanoparticles with a lipid core and shell structures as protein drug carriers, wherein the nanoparticles are prepared by producing nano-sized particles from lecithin obtained from natural soybean, and then adsorbing polaxamer thereon. Here, lecithin is used as an ingredient of core structure, polaxamer is used as an ingredient of shell structure, and both ingredients are applicable to a human body. Thus-obtained nanoparticles having a lipid core and shell structures are applicable in the clinical application. Moreover, said nanoparticles are suitable for use as a drug carrier or a diagnostic agent because they are produced in an aqueous solution without organic solvents.
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