GENE DELIVERY FORMULATIONS AND METHODS FOR TREATMENT OF ISCHEMIC CONDITIONS

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United States of America Patent

APP PUB NO 20090209630A1
SERIAL NO

12114330

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ATTORNEY / AGENT: (SPONSORED)

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Abstract

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The present inventors have developed a novel approach for efficient delivery of angiogenic factors to the cardiac and peripheral vasculature that avoids problems with toxicity inherent to existing delivery technologies. Vectors carrying coding sequences for angiogenic agents including Del-1 or VEGF, or both, can be formulated with poloxamers or other polymers for delivery into ischemic tissue and delivered to areas of peripheral ischemia in a flow to no-flow pattern and to the heart by retrograde venous perfusion.

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Patent Owner(s)

Patent OwnerAddress
VICAL INCORPORATEDSAN DIEGO CALIFORNIA 92121-4340

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Coleman, Michael E Hauts-de-seine , FR 24 248
MacLaughlin, Fiona Belfast , IE 8 138
Nordstrom, Jeffrey College Station , US 1 3
Thiesse, Mary L Houston , US 4 47
Wang, Jijun Pearland , US 12 92
Young, Stuart Portola Valley , US 26 744

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