ANTISENSE COMPOUNDS HAVING ENHANCED ANTI-MICRORNA ACTIVITY
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United States of America Patent
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Issued Date -
Aug 13, 2009
app pub date -
Aug 29, 2006
filing date -
Aug 29, 2005
priority date (Note) -
Abandoned
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Abstract
Antisense compounds, compositions and methods are provided for modulating the levels expression, processing and function of miRNAs. The antisense compounds exhibit enhanced anti-miRNA activity. Further provided are methods for enhancing the inhibitory activity of an antisense compound targeting a miRNA, comprising incorporating stability enhancing sugar modifications into the antisense compounds.
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