BMP4 INHIBITORS
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United States of America Patent
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Issued Date -
Aug 13, 2009
app pub date -
Apr 23, 2007
filing date -
Apr 21, 2006
priority date (Note) -
Abandoned
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Abstract
A fragment of Gremlin having the sequence of amino acids shown in SEQ ID NO:2 or a functional subsequence of the fragment is described. The fragment is capable of altering BMP4 activity. Also provided is a polynucleotide encoding the fragment. Also disclosed is an assay for testing a molecule for Gremlin inhibitory activity. The invention also provides a method of inhibiting BMP4 activity.
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