METHODS OF OPTIMIZING ANTIBODY VARIABLE REGION BINDING AFFINITY
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United States of America Patent
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Issued Date -
Aug 13, 2009
app pub date -
Oct 28, 2004
filing date -
Oct 22, 2004
priority date (Note) -
Abandoned
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Abstract
The present invention provides optimized heteromeric variable region binding fragments and antibodies comprising optimized heteromeric variable region binding fragments. Preferably, the optimized heteromeric variable region binding fragments exhibit optimized activity compared to donor heteromeric variable regions and have unvaried human frameworks. The present invention also provides methods of making the optimized heteromeric variable region binding fragments.
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