Crystalline Polymorphs of Topotecan Hydrochloride and Methods for the Preparation Thereof
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United States of America Patent
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Issued Date -
Jul 30, 2009
app pub date -
Dec 3, 2008
filing date -
Dec 4, 2007
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Abstract
The invention relates to two novel crystalline form of Topotecan hydrochloride (Ia)Herein referred to as forms α and β, characterized by high purity and whose preparation is advantageous from the industrial point of view. Form α can be in fact conveniently prepared starting from 10-hydroxy-camptothecin, whereas form β can be prepared starting from form α.
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