Method for Freeze-Drying Nucleic Acid/Block Copolymer/Cationic Surfactant Complexes
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app pub date -
Mar 19, 2009
filing date -
Dec 23, 2002
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Abstract
This invention relates generally to the freeze-drying of formulations comprising a polynucleotide, a block copolymer and a cationic surfactant. In the presence of a cryoprotectant or bulking agent, a formulation can be freeze-dried, whereby upon reconstitution of the dried formulation, the microparticles maintain their optimal size and aggregation or fusion is avoided.
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