Use of PARP-1 Inhibitors
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United States of America Patent
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Issued Date -
Jul 2, 2009
app pub date -
Nov 27, 2006
filing date -
Nov 25, 2005
priority date (Note) -
Abandoned
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Abstract
A method for improving the cytotoxic effect of Ecteinascidin-743 (ET-743) or an analog thereof on a tumor cell population in a patient the method including administering to the patient, sequentially or simultaneously, a therapeutically effective combination of a composition including ET-743 and an amount of a composition including a PARP-1 inhibitor effective to increase the cytotoxic effect of ET-743 on the tumor cell population. Anti-tumor compositions containing a therapeutically effective amount of ET-743 and an amount of a PARP-1 inhibitor effective to increase the tumor cytotoxicity of the ET-743 are also presented.
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