Azetidine Derivatives as Inhibitors of Stearoyl-Coenzyme a Delta-9 Desaturase
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Jul 2, 2009
app pub date -
Jun 8, 2007
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Jun 12, 2006
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Abstract
Azetidine derivatives of structural formula I are selective inhibitors of stearoyl-coenzyme A delta-9 desaturase (SCD1) relative to other known stearoyl-coenzyme A desaturases. The compounds of the present invention are useful for the prevention and treatment of conditions related to abnormal lipid synthesis and metabolism, including cardiovascular disease; atherosclerosis; obesity; diabetes; neurological disease; metabolic syndrome; insulin resistance; liver steatosis; and non-alcoholic steatohepatitis. (I)
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