Anchor-Assisted Fragment Selection and Directed Assembly
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United States of America Patent
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Issued Date -
Jun 25, 2009
app pub date -
May 31, 2006
filing date -
May 31, 2005
priority date (Note) -
Abandoned
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Abstract
The invention provides methods for compound and lead generation and discovery. In particular, the present invention provides a method for generating compounds and for selecting compounds that bind to a target. The present invention provides a way by which anchors (e.g., weak binders) and anchor-scaffold conjugates can be evolved into new generations of compounds having improved target binding and other desired pharmaceutical properties through control of both synthetic input and selection criteria.
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