METHODS AND COMPOSITIONS FOR INHIBITING UNDESIRABLE CELLULAR PROLIFERATION BY TARGETED LIPOSOME DELIVERY OF ACTIVE AGENTS
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United States of America Patent
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Issued Date -
Jun 25, 2009
app pub date -
Sep 19, 2008
filing date -
Sep 19, 2007
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Abstract
Provided are methods for inhibiting undesirable proliferation of a tumor cell or a tumor in a subject including administering to the subject a composition that includes an effective amount of an active agent, wherein the active agent is entrapped by one or more liposomes, the active agent has activity in inhibiting undesirable proliferation of the tumor cell or the tumor, and the one or more liposomes include one or more targeting agents that preferentially or specifically bind to a binding molecule expressed by the tumor cell or the tumor, present on the tumor cell or the tumor, present in the tumor cell or the tumor, or combinations thereof. Also provided are compositions for treating tumors, particularly gliomas, in a subject in need thereof.
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