METHODS OF TREATING BLOOD CELL DEPLETION
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United States of America Patent
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Issued Date -
Jun 18, 2009
app pub date -
Jul 24, 2008
filing date -
Jul 30, 2007
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Abandoned
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Abstract
Provided herein are methods and compositions useful for the replenishment of blood cells in a mammal after exposure to therapeutic radiation or drugs. Radiation illness can be reduced in animals by treatment with substance P analogs. In one embodiment, granulocytes can be regenerated after therapeutic radiation by the administration of a substance P analog. In one embodiment, substance P analogs are useful for reducing PARP activity or PARP expression. In one embodiment, substance P analogs are useful for preventing, reducing or ameliorating adverse effects of drugs. In one embodiment, drug induced blood dyscrasias can be ameliorated by the methods and compositions provided herein.
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