Trimeric IL-1Ra
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United States of America Patent
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Issued Date -
Jun 4, 2009
app pub date -
Oct 8, 2008
filing date -
Oct 8, 2007
priority date (Note) -
Abandoned
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Abstract
Interleuekin-1 receptor antagonists (IL-1Ra) including fusion proteins having a trimerizing domain and an IL-1Ra polypeptide sequence. The fusion proteins are part of trimeric complexes that are used in pharmaceutical compositions for treating diseases mediated by IL-1. Effective treatment of inflammatory diseases, such as rheumatoid arthritis and diabetes, are described.
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