Methods for treating autoimmune disease by inducing autoantigen-specific regulatory CD4+ T cells
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United States of America Patent
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Jul 21, 2020
Grant Date -
Jun 4, 2009
app pub date -
Oct 27, 2008
filing date -
Apr 25, 2006
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Abstract
Described herein are methods and compositions for the treatment and monitoring the progress of autoimmune diseases. In some embodiments, the methods include the stimulation of regulatory T cells specific to autoantigens associated with the autoimmune disease. A specific embodiment relates to diabetes mellitus, and the prevention or delay of loss of residual β-cell mass, providing a longer remission period and delaying the onset of diabetes related, progressive, complications through immunotherapeutic induction of regulatory T cells specific for human insulin B chain. In addition, the methods described herein can be used to predict whether a subject, e.g., a subject with ongoing anti-insulin autoimmunity, will progress to T1DM, and to evaluate a subject's response to a therapeutic intervention.
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