Stable vaccine formulation

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United States of America Patent

SERIAL NO

12323708

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ATTORNEY / AGENT: (SPONSORED)

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Abstract

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An aqueous vaccine composition comprises a protein adsorbed on a solid and one or more stabilising agents, further characterized in that

    • (i) the system is optionally substantially free of a conventional buffer, i.e a compound with pKa within 1 unit of the pH of the composition at the intended temperature range of storage of the composition;
    • (ii) the pH of the composition is set to a value at which the composition has maximum measurable stability with respect to pH; and
    • (iii) the one or more additives are capable of exchanging protons with the said protein and have pKa values at least 1 unit more or less than the pH of the composition at the intended temperature range of storage of the composition.

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Patent Owner(s)

Patent OwnerAddress
ARECOR LIMITEDSAFFRON WALDEN CAMBRIDGESHIRE CB10 1XL

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Jezek, Jan Wellingborough, GB 73 261

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