MICROCHANNEL SURFACE COATING
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United States of America Patent
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Issued Date -
May 21, 2009
app pub date -
Oct 23, 2008
filing date -
Oct 25, 2007
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Abstract
The present invention relates to a method for improving the efficiency of biochemical reactions in channels of microfluidic devices. More specifically, the present invention relates to the use of chitosan or a chitosan derivative for coating channel surfaces to reduce non-specific adsorption of reagents to microfluidic channels. This reduction of non-specific adsorption improves the efficiency and reproducibility of the reaction, e.g., amplification reactions, such as PCR, and reduces cross-contamination.
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