METHODS AND COMPOSITIONS FOR THE TREATMENT OF ERYTHROCYTE DISEASES

Number of patents in Portfolio can not be more than 2000

United States of America Patent

APP PUB NO 20090124566A1
SERIAL NO

12134574

Stats

ATTORNEY / AGENT: (SPONSORED)

Importance

Loading Importance Indicators... loading....

Abstract

See full text

Methods to determine the susceptibility of a subject to erythrocyte diseases are provided. The methods comprise determining the miRNA compositions of erythrocytes from the subject. The present invention has discovered that erythrocytes comprise microRNA (miRNA) populations and the populations can be profiled or analyzed and used to determine the susceptibility for disease. The miRNA compositions can also be used to determine the severity of erythrocyte disease, and the features and clinical phenotypes of the erythrocyte disorders. Also provided are pharmaceutical compositions comprising erythrocyte miRNAs and methods for the treatment of a subject with an erythrocyte disease. In other embodiments of the invention, the miRNAs can be used to increase the life-span of erythrocytes through the introduction of an erythrocyte miRNA.

Loading the Abstract Image... loading....

First Claim

See full text

Family

Loading Family data... loading....

Patent Owner(s)

Patent OwnerAddress
DUKE UNIVERSITYBOX 90083 OFFICE OF SCIENCE & TECHNOLOGY DURHAM NC 27708

International Classification(s)

Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Chen, Shao-Yin Taipei City , TW 2 10
Chi, Jen-Tsan Chapel Hill, US 8 50
Lamonte, Gregory Durham, US 1 10

Cited Art Landscape

Load Citation

Patent Citation Ranking

Forward Cite Landscape

Load Citation