Copper-dependent non-traditional pro-inflammatory cytokine export and methods, compositions and kits relating thereto
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United States of America Patent
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Issued Date -
Sep 21, 2006
app pub date -
May 22, 2006
filing date -
Aug 24, 2001
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Abandoned
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Abstract
The present invention relates to the discovery that non-traditional export of certain pro-inflammatory cytokines lacking a signal sequence from a cell can be inhibited by copper chelation and/or administration to the cell of a truncated form of S100A13 lacking the basic residue portion. Further, copper chelation inhibits, inter alia, neointima formation, macrophage infiltration and associated inflammation, cell proliferation, secretion of extracellular matrix, intimal thickening, adventitial angiogenesis, restenosis, and the like, associated with vascular vessel injury. Thus, the present invention provides novel methods of preventing and treating, and for identifying novel compounds also useful as therapeutics for, such conditions.
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