DROPLET-BASED DIGITAL MICRODIALYSIS
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United States of America Patent
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Issued Date -
Apr 30, 2009
app pub date -
Oct 24, 2007
filing date -
Oct 24, 2007
priority date (Note) -
Abandoned
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Abstract
The invention relates to a droplet-based digital microdialysis method that utilizes discrete perfusate droplets marched through a microchannel in an intermittent manner. The droplets sequentially reside on a microdialysis membrane that is in contact with the test fluid, e.g., fluid in an extracellular space. The droplets remain stationary at the membrane site for a period of time for rapid equilibration with the test fluid, and is then marched to an outlet port for processing. The invention further relates to microdialysis probes and methods based on the droplet-based digital microdialysis.
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