Stabilized Aptamers to PSMA and Their Use as Prostate Cancer Therapeutics
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United States of America Patent
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Issued Date -
Apr 23, 2009
app pub date -
Mar 7, 2006
filing date -
Mar 7, 2005
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Abstract
The present invention provides stabilized, high affinity nucleic acid ligands to PSMA. Methods for the identification and preparation of novel, stable, high affinity ligands to PSMA using the SELEX™ method with 2′-O-methyl substituted nucleic acids, and cell surface SELEX™ are described herein. Also included are methods and compositions for the treatment and diagnosis of disease characterized by PSMA expression, using the described nucleic acid ligands.
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