Method to Make a Peptide-Carrier Conjugate with a High Immunogenicity
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United States of America Patent
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Issued Date -
Apr 23, 2009
app pub date -
Dec 10, 2004
filing date -
Dec 18, 2003
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Abandoned
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Abstract
The present invention provides a method for making a peptide-carrier conjugate. The method comprises modifying a first peptide to produce a second peptide so that the pI of the second peptide is in a favorable range or closer to the range than the pI of the first peptide, and conjugating a plurality of the second peptide to OMPC to obtain a peptide-carrier conjugate. The peptide load, or the solubility of the conjugate, or both of them are increased by the modification.
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