Azacyclohexane derivatives as inhibitors of stearoyl-coenzyme a delta-9 desaturase
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Apr 16, 2009
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Jun 8, 2006
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Jun 9, 2005
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Abstract
Azacyclohexane derivatives of structural formula I are selective inhibitors of stearoyl-coenzyme A delta-9 desaturase (SCD1) relative to other known stearoyl-coenzyme A desaturases. The compounds of the present invention are useful for the prevention and treatment of conditions related to abnormal lipid synthesis and metabolism, including cardiovascular disease, atherosclerosis; obesity; diabetes; neurological disease; metabolic syndrome; insulin resistance; and liver steatosis.
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