Method for Detecting Large Mutations and Duplications Using Control Amplification Comparisons to Paralogous Genes
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United States of America Patent
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May 9, 2008
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Jul 12, 2005
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Abstract
Methods for querying biological samples to detect genetic mutations, particularly insertions and deletions, by co-amplification of a gene of interest in conjunction with a paralogous gene. When the gene of interest and the corresponding paralogous gene are selected from the CYP450 family, the resulting ratios may predict how a particular patient metabolizes certain prescription drugs.
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