Compositions and methods for in vivo SELEX
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United States of America Patent
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Issued Date -
Mar 26, 2009
app pub date -
Jul 21, 2008
filing date -
Jul 20, 2007
priority date (Note) -
Abandoned
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Abstract
The invention describes methods for the in vivo selection of oligonucleotides, preferably aptamers, that persist in biological compartments. In one embodiment, the biological compartment comprises at least one tissue which, in a preferred embodiment, is the blood within the circulatory system of a living mammal. The invention also contemplates oligonucleotides, preferably aptamers, selected through in vivo SELEX that may be linked to therapeutic or diagnostic compositions including other oligonucleotides.
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